From Porto to the prehistoric rock carvings of Foz Coa, you can cross Portugal from West to East connecting the dots representing four World Heritage Sites: Porto, Guimaraes, Alto Douro, and Foz Coa. Most of it along the Douro river, famous for wine.
The Douro valley is following a plan based on Sustainable Tourism, and has a web site that explains it all to you: Douro Valley Sustainable Tourism Initiative. It’s an interesting site.
And just in case you’d like to drive an interesting route, and stop at scenic places, Visit Portugal has an interesting page which points out Five views of the Douro
All of this points out some of the most evocative rural spaces in Portugal, full of tradition and hearty food, which is celebrated with the wine in autumn. Now is a great time to plan a trip.
More Travel Planning Resources: Porto Weather and Climate | Portugal Rail Map